Ventilation-induced Alterations in Lung Development Kroon, A.A. 2011-12-21 Doctoral Thesis

 Mechanical ventilation is a lifesaving treatment in critically ill neonates. However, mechanical ventilation is also one of the most important risk factors (Table 1) of Bronchopulmonary dysplasia (BPD), the most common chronic lung disease in infancy with long-term pulmonary and neurological complications (1). Exposure of immature lungs to positive pressure ventilation results in oxidative stress and ventilator-induced lung injury. The resulting injury and inflammation lead to abnormal developmental and reparative processes in the lung. This general introduction outlines the current knowledge regarding Bronchopulmonary dysplasia related to lung development, mechanisms of ventilator-induced lung injury, mechanosensing and mechanotransduction and pathways involved in the pathogenesis of BPD related to mechanical ventilation.
http://repub.eur.nl/res/pub/30803/111221_Kroon%2C%20Andreas%20Aloysius%20-%20BEWERKT%20-.pdf