The paraganglion system is composed of a collection of chromaffin cells that is
distributed throughout the body. Embryonically, chromaffin cells arise from the
neuroectodermal tissue of the neural crest and are thought to migrate along the
innervating nerves or vasculature towards their primordial location to form the
paraganglia. The largest paraganglion is the adrenal medulla, an important
neuroendocrine organ, which is the body’s main source of catecholamines (adrenalin,
noradrenalin and dopamine). The adrenal medulla receives input from the sympathetic
nervous system through preganglionic fibers upon which it releases its secretions directly
into the blood. Besides this adrenal station there are many extra‐adrenal paraganglia that
are distributed along the body axis and located in the proximity of ganglia of the
sympathetic chain or in association with cranial nerves and blood vessels.
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