The objectives of this thesis were: (1) To assess all literature
concerning prophylactic treatment of migraine in children and adolescents; (2) To
describe and evaluate the literature concerning the occurrence and manifestations of
psychological (dys)functioning and/or psychiatric comorbidity in children and adolescents
with migraine in clinical studies; (3) To evaluate generic health-related Quality of Life (QoL)
in children and adolescents with primary headache at an outpatient department in a
general hospital; (4) To assess the efficacy of medium-dose riboflavin as a prophylactic
drug in childhood migraine; (5) To study generic health-related QoL and psychological
functioning as outcomes in a prophylactic intervention study in children with migraine;
(6) In a prospective study to investigate sleep deprivation as a potentially causative factor
for headache attacks in childhood migraine, and to explore the effect of resting and
sleeping after the start of the headache attack on headache symptoms.
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