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Tuesday, February 28, 2012

Quality of Life and Psychological Functioning in Observational and Intervention Studies in Childhood Migraine Bruijn, J.K.J. 2010-09-29 Doctoral Thesis Neurology


The objectives of this thesis were: (1) To assess all literature concerning prophylactic treatment of migraine in children and adolescents; (2) To describe and evaluate the literature concerning the occurrence and manifestations of psychological (dys)functioning and/or psychiatric comorbidity in children and adolescents with migraine in clinical studies; (3) To evaluate generic health-related Quality of Life (QoL) in children and adolescents with primary headache at an outpatient department in a general hospital; (4) To assess the efficacy of medium-dose riboflavin as a prophylactic drug in childhood migraine; (5) To study generic health-related QoL and psychological functioning as outcomes in a prophylactic intervention study in children with migraine; (6) In a prospective study to investigate sleep deprivation as a potentially causative factor for headache attacks in childhood migraine, and to explore the effect of resting and sleeping after the start of the headache attack on headache symptoms.

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