In humans, the natriuretic peptide family consists of three different types of
peptides: atrial natriuretic peptide (synonym: atrial natriuretic factor), B-type
natriuretic peptide (synonym: brain natriuretic peptide) and C-natriuretic
peptide.1 Atrial natriuretic peptide (ANP) was the fi rst natriuretic peptide to
be discovered and in humans ANP is predominantly formed in the cardiomyocytes
of the atria.2 B-type natriuretic peptide (BNP) was fi rst discovered in
porcine brain hence its original name brain natriuretic peptide.3 In humans,
the majority of BNP is formed in ventricular cardiomyocytes, and mRNA levels
in brain are negligible. Therefore, brain natriuretic peptide is now recognized
as B-type natriuretic peptide. C-type natriuretic peptide (CNP) is basically a
neuropeptide, found in brain and vascular endothelial cells.http://repub.eur.nl/res/pub/21416/101123_Rutten%2C%20Joseph%20Henricus%20Wilhelmus.pdf
No comments:
Post a Comment