This thesis describes the clinical effects of proton pump inhibitors, with
focus on pharmacogenetics, kinetics and dynamics. The aims were to
investigate the occurence of Rebound Acid Hypersecretion and to
investigate the speed of onset, the duration of effect and the difference
in acid-inhibition between esomeprazole, rabeprazole and pantoprazole.
Furthermore the prevalence of CYP2C19 polymorphism was studied in a
Caucasian population. The influence of CYP2C19 polymorphism on
acid-inhibition and pharmacokinetics of proton pump inhibitors in
Caucasians was also studied.http://repub.eur.nl/res/pub/21086/100924_Hunfeld%2C%20Nicole%20Geertruida%20Maria.pdf
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