This doctoral thesis concerns the treatment of liver cancer patients using
external beam radiotherapy. The quality of this treatment greatly depends
on delivering a high radiation dose to the tumor while keeping the dose as
low as possible to surrounding healthy tissues. One of the major
challenges is locating the tumor at the moment of dose delivery. In this
ork, the uncertainty of locating the tumor was investigated. For this
purpose, gold markers were implanted in the liver tissue and visualized on
X-ray images. The markers were used to measure day-to-day tumor mobility
and motion
due to respiration. Furthermore, it was found that major improvements in
the targeting accuracy can be achieved by using the markers for guiding
the treatment procedure.http://repub.eur.nl/res/pub/23257/110304_Wunderink%2C%20Wouter.pdf
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