terotactic Body Radiation Therapy for Liver Tumors Méndez Romero, A.M. 2011-03-04 Doctoral Thesis

As a common deposit for tumor cells, the liver is second only to the lymph nodes as a site of metastatic disease. Unfortunately, by the time patients present with liver metastases there is usually evidence of the systemic spread of the disease, and patients can not longer be considered as candidates for surgery or other local ablative treatments. Because the liver is the first major organ reached by venous blood draining from the intestinal tract, it is the most common site of metastatic disease in cancers of the large intestine. It is involved in as many as 50-70% of colorectal cancer patients who develop metastatic disease, in approximately half of whom it is the only site of recurrence. While the role of local treatments such as surgery and radiofrequency ablation (RFA) is relatively well defined for colorectal metastases, their indications and benefits are less clear in metastases from other tumor types. However, due to concomitant medical diseases or to poor anatomical location or performance status, few patients with colorectal liver metastases are considered eligible for resection.

http://repub.eur.nl/res/pub/22642/110304_Mendez%20Romero%2C%20Alejandra%20Maria.pdf