The role of SOCS3 signaling in ulcerative colitis and ulcerative colitis-related carcinogenesis Li, Y. 2012-01-11 Doctoral Thesis

 Cytokine-signaling plays an important role in IBD. Proinflammatory cytokines like IL-6 contribute to the protection against pathogens, whereas they are also involved in chronic inflammation and are able to drive the survival and proliferation of cancer cells. Anti-inflammatory cytokines like IL-10 could help-out with the resolution of inflammation or prevent autoimmunity. On the other hand these anti-inflammatory cytokines can contribute to cancer development by inhibiting proper immune surveillance. All these effect warrant proper regulation of cytokine-signaling especially in a complex environment like the intestinal mucosa. In this thesis we focus on the role of SOCS3 the inhibitor of STAT3-signaling and its role in UC and UC-related CRC.
http://repub.eur.nl/res/pub/30808/120111_Li%2C%20Yi.pdf