Rheumatoid arthritis (RA) was originally thought to be a T-helper (Th)1- but not a Th2-
associated disorder; however, it currently is unclear whether RA is a Th1- and/or Th17-
mediated disease, and what the contributions of these T-cell subsets are in the pathogenesis
of RA. Results from studies using different arthritis models have demonstrated that IL-17-
producing T-cells are the dominant cell type in the development of arthritis. In addition, a
critical role of the IL-23/IL-17 axis in the progression to chronic destructive arthritis has
been demonstrated. Interestingly, Th1 and Th17 cells both may have unique pathogenic
potential, and the recent insights into T-cell plasticity may change the understanding of
the role of T-cell subsets in chronic autoimmune diseases.
http://repub.eur.nl/res/pub/30678/111221_Cornelissen%2C%20Fredericus%20Hermanus%20Johannes.pdf
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