Cell biological processes require intense and continuous regulation.
This often involves complex systems that, when disturbed, fail to
generate the desired outcome and finally result in diseases. Defects in
these systems can have different origins. For example, the translation
of the genes can be misregulated, leading to altered protein expression
levels. Alternatively, genes can encode for mutated, truncated or
chimeric fusion proteins, altering the function and activity of that
protein. On the other hand, the defects can also originate from the
regulation of the activity of otherwise correctly functional proteins.
These regulation systems often rely on chemical modifications of the
proteins, and these are also frequently perturbed in diseases. The focus
of this thesis will be on one such important modification:
ubiquitination.
http://repub.eur.nl/res/pub/26843/111109_Faesen%2C%20Alexis%20Casper.pdf
http://repub.eur.nl/res/pub/26843/111109_Faesen%2C%20Alexis%20Casper.pdf
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