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Thursday, February 9, 2012

Activity modulation of Ubiquitin-Specific Proteases Faesen, A.C. 2011-11-09 Doctoral Thesis

Cell biological processes require intense and continuous regulation. This often involves complex systems that, when disturbed, fail to generate the desired outcome and finally result in diseases. Defects in these systems can have different origins. For example, the translation of the genes can be misregulated, leading to altered protein expression levels. Alternatively, genes can encode for mutated, truncated or chimeric fusion proteins, altering the function and activity of that protein. On the other hand, the defects can also originate from the regulation of the activity of otherwise correctly functional proteins. These regulation systems often rely on chemical modifications of the proteins, and these are also frequently perturbed in diseases. The focus of this thesis will be on one such important modification: ubiquitination.
http://repub.eur.nl/res/pub/26843/111109_Faesen%2C%20Alexis%20Casper.pdf 

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