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Monday, March 5, 2012

Helicobacter pylori-associated malignancies: Genetics, Epidemiology and Gastric Cancer Risk Capelle, L.G. 2010-09-03 Doctoral Thesis

Helicobacter pylori infection affects at least 50% of the world population. The chronic inflammation caused by H. pylori can progress to pre-malignant gastric lesions, gastric adenocarcinoma and gastric MALT lymphoma. The widespread high prevalence of H. pylori explains that gastric cancer remains the fourth most common cancer and second leading cause of cancer related death worldwide. For these reasons, data on epidemiology and screening and surveillance options for gastric cancer in patients with H. pylori-associated malignancies may lead to a reduction in gastric cancer mortality. In the first chapter the aims and outline of this these are described. In the second chapter of this thesis we describe a pilot study on the association between H. pylori susceptibility and genetic factors.
http://repub.eur.nl/res/pub/20708/100903_Capelle%2C%20Lisette%20Geraldine.pdf 

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