Much work over the past two decades supports the concept that
schizophrenia involves a disruption in the orchestration of the multiple neural
networks that participate in higher cognitive functions. The connectivity
between neural networks arising during normal development is potentially
disrupted, leading to the recruitment of either inappropriate regions for task
execution, or alternatively, alters the processing requirements in expected regions.
For example, studies utilizing both glucose metabolism (FDG-PET), SPECT, and
H2O15 PET have demonstrated hypofrontality in the dorslolateral prefrontal cortex
(DLPFC) on tasks of executive function. Additionally, studies utilizing
diffusion tensor imaging (DTI), which measures the coherence of neuronal fiber
tracts, have shown a decrease in the coherence of white matter tracts in
schizophrenia. This is presumed to be additional evidence for disrupted
connectivity in schizophrenia.http://repub.eur.nl/res/pub/20538/100901_White%2C%20Tonya%20Jo%20Hanson.pdf
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